Antidepressant Drugs: Types, Effects and Developments

Antidepressant Drugs: Types, Effects and Developments Introduction: Depression is one of the parts of mental disorder which is affecting millions of people worldwide. [6] The logical analytical approach used in clinical and forensic toxicology for the identification of one or more Antidepressant Drugs as a cause of intoxication is largely based on both simple and fast screening methods which cover their extraction and identification including detection of their possible metabolites is been tried to reviewed. Antidepressant: Types Functions Antidepressant drugs cover many varieties of drugs having different modes of actions like [16] etc. Adverse effects Antidepressants are supposed to increase the risk of suicidal thinking and behavior in children accompanying other disorders like depressive and psychiatric disorders. [17] [18] [19] The European Medicines Agency showed warning on the use of Antidepressants which might be increased the risk of suicidal behavior in children and adolescents. [31] TCAs and MAOIs can produce similar kind of side effects like Tachycardia, blurred vision, urinary retention, cardiovascular effects , hypotension, respiratory depression, coma etc. [4] Thus, these drugs may be responsible for the fatality and intoxication and can produce severe effects. Also their growing rate all over the world may show threatening effects which is the matter of global concern. Thus, its increasing prescription rate and adverse effects resulting in a growing interest for determination methods in the Clinical and Forensic field. Biological Samples use for the Screening of Antidepressant Drugs Biological samples are the basic requirement of Forensic and Clinical Toxicology as it solve several related questions which make basis of judgement, consultation and expertise for the above two fields. The matrices generally encountered for analysis are urine [34], hair, nails, vitrous humour etc. The most important biosample used for analytical purposes is Blood. It is a liquid connective tissue of the body composed of different kinds of blood cells suspended in a fluid called plasma. Blood (plasma, serum) is one of the best choices for quantitative and qualitative measurements of drugs of interest because pharmacological or toxicological effects correlate more effectively with their concentrations in blood. [42] Another important biological sample is Urine which is a widely used specimen employed for screening, identification and testing of unknown drugs, forms in high amount, readily available, easy to collect and contains much useful information about the major metabolic functions of the body. [43] Taking Forensic concept in postmortem cases if the positive finding of drug occurs in urine shows that the detected substance or its parent compound might be present in the body some time before death [48] A next alternative to the blood and urine specimen found is Oral fluid for their applications in therapeutic and toxicological drug monitoring [54] When analytical studies get concern with long duration of exposure to the detection window Hair could be as a best biological matrix for the identification and analysis of drugs. It is supposed that drugs or chemicals enter in to hair by passive diffusion from blood capillaries into growing cells and the mechanisms of substance incorporation, analytical methods, result interpretation and practical applications of hair analysis has been well reviewed showing practical utility of hair analysis. [62] Except from all the above given matrices one very precise and rarely encountered biological sample is Vitreous Humor. Its a fluid found between the lens and retina of the eye proved to be the best choice for analytical examinations as it is relatively well isolated and protected from putrefaction. Two different fatality cases were reported where the extraction of drugs is done from Vitreous humor. One case has been reported of citalopram fatality where the extraction of drug is done from Vitreous humor yeilding concentration of citalopram (SSRI) less than 0.04mg/L and in second case venlafaxine fatality is reported where postmortem analysis revealed the concentrations of Fluoxetine (SSRI) and its metabolite Norfluoxetine as 5.2 mg/l and 2.2mg/l respectively. [64] Other than these specimens, body tissues like liver [71], cerebrospinal fluid etc. canalso encounter for toxic and therapeutic drug monitoring biological matrices. Techniques for Sample Preparation Several methods have been published for the determination of one or more antidepressants in biological fluids for therapeutic monitoring or for toxicological purposes. For making biological samples suitable for analytical purposes some treatments should be given to overcome the matrix effects such that the other materials should not interfere with the analytical separation that is the extractability of the analytes in the sample inturn the results of the analysis. [96] These kinds of techniques are rapidly gaining acceptance in bioanalytical applications to reduce both time and labor required to produce bioanalytical results. Thus we can say that these methods give a high selectivity and sensitivity over a wide dynamic range and contribute in formulating very fine detection techniques. Some Commonly Prescribed New Generation Antidepressant Drugs and their Metabolites Several new antidepressants that inhibit the Serotonin (SERT) and Norepinephrine transporters (NET) have been consistently use for therapeutic purposes. [108] are showing below. Sertraline is an effective and highly utilized SSRIs group of drug and â€Å"its principle metabolite is desmethylsertraline.† [41] Another SSRIs group of Antidepressant drug, Fluoxetine has been used worldwide in the therapy of major depression. (3) â€Å"It is primarily metabolized via N-demethylation by the [117] Citalopram is a selective and potent serotonin reuptake inhibitor. [78] Another very important group of Antidepressant drug is SNRIs which includes drugs like Venlafaxine which inhibits serotonin, noradrenaline, and to a lesser extent dopamine reuptake. [39] In the majority of published analytical methods for determination of Antidepressant drugs, gas chromatography and high-performance liquid chromatography, in combination to different kinds of colums operating under different separation conditions, mobile phases and detectors has been used. These were tried to review in the table given below. With high-performance liquid chromatography the analysis is done by using different kinds of detectors like Fluorescence detector, UV detector, Mass detectors etc. For ex. a high-performance liquid chromatographic method is described for the determination of serotonin and norepinephrine reuptake inhibitor (SNRI) in human plasma where Fluorescence detector was used. [140] A survey of most recent multiresidue analytical methods developed for the determination of different kinds of Antidepressant drugs in different types of biological test matrices with their specific cleanup procedures including the choice of mobile phase, stationary phase, detector system and validation data is summarized in the tabular form below. TABLE Abbreviations:APCI atmospheric pressure chemical ionisation, ESI eletrospray ionisation, LLE liquid-liquid extraction, LOD limitation of detection, LOQ limit of quantification, SIM single ion monitoring, SPE solid-phase extraction, SRM selected reaction monitoring , ESI electron spray ionization, UV ultraviolet, FD fluorescence detector, LC_TMS liquid chromatography tandom mass spectrometry, LC_MS, GC_MS gas chromatography mass spectrometry, RP-HPLC reverse phase high performance liquid chromatography. Thus, this table is framed for the comparative study of the major analytical approaches used in the detection and identification of Antidepressant Drugs and their metabolites in different biological matrices in order to develop the new methods with the aim to increase the sample throughput and to improve the quality of analytical methods. Thus, analytical methods for the detection of ADs and their metabolites in biological matrices are of interest in the field of forensic toxicology which involves the analysis of drugs and poisons in biological specimens and interpretation of the results to be applied in a court of law. Several analytical methods have been developed for analysis of these antidepressants in biological matrices. These methods provide a good precision and accuracy over the entire analytical range and allowing the development of very rapid and efficient analytical methods by using newer kind of analytical techniques. Conclusion: As the subject of Antidepressants toxicity is evolving, newer methods for their analysis are also evolving. However, some classes of Antidepressants drugs are less toxic and well tolerated but can lead to Toxic or Fatal Drug interaction. The research in this field is very active and results in a large number of papers published every year. Therefore they may be encountered in many Clinical and Forensic cases. Therefore, this review is mainly aimed to target latest analytical and instrumental methods used for detection and characterization of Antidepressant drugs and their metabolites in biological test matrices in turn focus on their toxic as well as therapeutic aspects which would be definitely prove to be helpful in future research and still there is lots of work required in this area as its prescription rate and toxicity is evolving day by day all over the world and by using non-destructive and sophisticated newer instrumental techniques we can also built a new strategy of examina tion and investigation for the drugs of interest. However, in this study, a decision about whether a studys findings are positive or negative cannot always be based strictly on the primary outcome measure. Future trials should also consider, using different kinds of detecting techniques and methods which would allow for easier comparison and interpretation of results across studies as the subject is of global concern and despite the success of such methods there is a continuing need for sustained innovations. Thus, future work in this area will definitely prove to be a promising from both clinical as well as from forensic prospect.

Loneliness to Insanity and Madness in A Rose for Emily and The Yellow W

From Loneliness to Insanity in A Rose for Emily and The Yellow Wall-Paper      Ã‚   In The Second Sex, Simone de Beauvoir states that within a patriarchal society "woman does not enjoy the dignity of being a person; she herself forms a part of the patrimony of a man: first of her father, then of her husband" (82-3). Both Emily Grierson in William Faulkner's "A Rose for Emily" and the narrator of Charlotte Perkins Gilman's "The Yellow Wall-Paper" are forced into solitude simply because they are women. Emily's father rejects all of her prospective mates; the husband of Gilman's narrator isolates her from stimulation of any kind. Eventually, Emily is a recluse trapped in a deprecated home, and the narrator in Gilman's story is a delusional woman confined to her bed. A study of the characterization and setting of "A Rose for Emily" and "The Yellow Wall-Paper" demonstrates how the oppressive nature of patriarchy drives the women in both stories insane.    The "patrimony of a man" destroys Emily as her father smothers her with his over-protectiveness. He prevents her from courting anyone as "none of the young men were quite good enough for Miss Emily and such" (82). When her father dies, Emily refuses to acknowledge his death; "[W]ith nothing left, she . . . [had] to cling to that which had robbed her" (83). When she finally begins a relationship after his death, she unfortunately falls for Homer Baron who "liked m... ...Jellife. Tokyo: Kenkyusha, 1956.    ---. Faulkner in the University. Ed. Frederick L. Gwynn and Joseph L. Blotner. Charlottesville: U of Virginia P, 1959.    ---. "A Rose for Emily." Literature: Reading, Reacting, Writing. Ed. Laurie G. Kirszner and Stephen R. Mandell. 3rd ed. Orlando: Harcourt, 1997. 80-87.    Gilman, Charlotte Perkins. "Why I Wrote 'The Yellow Wall-Paper.'" The Forerunner. October 1913. Online. An American Literature Survey Site. 14 November 1998. Available HTTP: www.cwrl.utexas.edu/~daniel/amlit/index.html    ---. "The Yellow Wall-Paper." Literature: Reading, Reacting, Writing. Ed. Laurie G. Kirszner and Stephen R. Mandell. 3rd ed. Orlando: Harcourt, 1997. 160-73.

Describe Place

Kelas Reguler Pagi dan Sore Mata Kuliah : Bahasa Inggris I Dosen : Restu Arini, S. Pd. Prodi : Semua Prodi Hari/Tanggal : Senin, 19 Nopember 2012 (Reg Sore) Selasa, 20 Nopember 2012 (Reg Pagi) Sifat : Take-Home Test Read the instruction carefully You are going to make video on your oral performance for Mid Test Project. The videos are based on the four topics we have discussed in classroom meeting (see the explanation in the box). The video can be made by using any recording media such as hand phone, handy cam, camera, etc which then should be compiled in one CD.You have got about 3 to 10 minutes to present each topic. Label your CD with your name, student number, and major. You are to submit the CD on the exam date. Read the explanation below of how you make t his project: Topic 1 : Introducing Yourself You must introduce yourself by mentioning the following things in your video; Introduce Your Name/Surname; describe Your Education Background; describe Your Competency; Describe Your Prospective Career; Describe Your Hobby, Your family, things you are doing and etc. You are allowed to add more information in order to make your vide o more interesting.Please go to these links to get better idea about how to deal with this topic: http://www. youtube. com/watch? v=CZCfTX oRzg&feature=autoplay&list=PLA7C7BF7961EB4606&playnext=2 http://www. youtube. com/watch? v=jiUdDxGlxvI http://www. youtube. com/watch? v=etIpPH5CEdA&feature=related Topic 2 : Description of People Read a biography book about famous people/group of people of any kind of professions (the person you are chosen might be an athlete, a musician, a comedian, a politician or even activists). The book can be written in English or in Bahasa Indonesia.An article taken from internet is not acceptable. Having finished reading the book you must make a description about him/her/them, in the following ways: ? The physical appearance ? The quality of the person using P-M-I Chart (see tool #1) Plus = you are about telling the quality of the person from the positive or good side. Minus = you are to discuss the person’s bad points. Interesting = you are to reveal the things or personality which made this person interesting, in other word his/her charisma or charm. Use the P-M-I Chart as a guideline to make your summary on the biography book you read.In the video, you do not have to show me the P-M-I Chart. You will be scored based on certain requirement (see Scoring Rubric #1) Please go to these links to get better idea about how to deal with this topic: http://www. youtube. com/watch? v=vVeojbg_JgI Arini. MidProject. English1. 2012 1 http://www. youtube. com/watch? v=tMMmJqh4qek http://www. youtube. com/watch? v=sqt_IbqJOLg http://www. youtube. com/watch? v=GrqEANtMqYo Topic 3 : Description of Object Choose an object of the following category: Furniture /Kitchen tools / Electronic Stuff s/ Vehicles / Office Equipments/Music InstrumentsMake a description on the object you choose. Give as detail information as possible. Go to these link to have clear idea about this topic: http://www. youtube. com/watch? v=H1mAtWACONM http://www. youtube. com/watch? v=kiyNYWGL-yg Topic 4 : Description of Place Choose two places to describe. The first is your hometown or place where you were born or place where you grew up. The second will be the place you are eager to visit. Here you may describe a specific place related to your dream or ambition. For example; you have a plan to continue study after finishing your bachelor degree.MidProject. English1. 2012 2 Scoring Rubric #1 (for description of people) 4 (standard of excellence) ? Develop detailed and convincing observation for each of three categories Identifies own conclusion and provides convincing and detailed rationale for choice ? Information is accurate, detailed, well, organized and presented with clarity 3 ( Exceed ? Develops convincing observation for each of the three categories acceptable ? Identifies own conclusion and provides detailed rationale for choice standard) ? Information is accurate and organized 2 ( meets ? Develop basic observation for each of the three categories acceptable ? Identifies own conclusion and provide rationale for choice standard) ? Information is accurate 1 ( needs improved ?Observation are incomplete and /or incorrect to meet acceptable ? Identifies own conclusion but does not explain rationale standard) ? Information is inaccurate, vague or missing Scoring Rubric #2 (for description of object and places) 4 (standard of excellence) ? Identifies multiple convincing and insightful examples of what a specific trait looks like/sound like/feels like ? Uses precise and detailed vocabulary to support description of examples 3 ( Exceed acceptable standard) ? Identifies multiple convincing examples of what a specific trait looks like/sound like/feels like Uses detailed vocabulary to support description of examples 2 ( meets acceptable standard) ? Identifies appropriate examples of what a specific trait looks like/sound like/feels like ? Uses appropriate vocabulary to support description of examples 1 ( needs improved to meet acceptable standard) ? Identifies examples of what a specific trait looks like/sound like/feels like that are erroneous or inappropriate ? Uses vocabulary that is vague and /or is incorrect Good Luck Arini. MidProject. English1. 2012 3

A Short Summary of the Persian Wars

The term Greco-Persian Wars is thought to be less biased against the Persians than the more common name Persian Wars, but most of our information about the wars comes from the winners, the Greek side—the conflict apparently was not important enough, or too painful for the Persians to record. For the Greeks, however, it was critical. As British classicist Peter Green has characterized it, it was a David and Goliath struggle with David holding out for political and intellectual liberty against the monolithic theocratic Persian war machine. It wasnt just Greeks against Persians, nor were all the Greeks always on the Greek side. Summary Locations:  Various. Especially Greece, Thrace, Macedonia,  Asia MinorDates:  c. 492–449/8 BCEWinner:  GreeceLoser:  Persia (under kings  Darius  and  Xerxes) Earlier than the (mostly failed) attempts by the Persian kings Darius and Xerxes to control Greece, the Achaemenid empire was enormous, and Persian King Cambyses had extended the Persian Empire around the Mediterranean coast by absorbing Greek colonies. Some Greek poleis (Thessaly, Boeotia, Thebes, and Macedonia) had joined Persia, as did other non-Greeks, including Phoenicia and Egypt. There was opposition: many Greek poleis under the leadership of Sparta on land, and under the dominance of Athens at sea, opposed the Persian forces. Before their invasion of Greece, Persians had been facing revolts within their own territory. During the Persian Wars, revolts within Persian territories continued. When Egypt revolted, the Greeks helped them. When Were the Greco-Persian Wars? The Persian Wars are traditionally dated 492–449/448 BCE. However, conflict started between the Greek poleis in Ionia and the Persian Empire before 499 BCE. There were two mainland invasions of Greece, in 490 (under King Darius) and 480–479 BCE (under King Xerxes). The Persian Wars ended with the Peace of Callias of 449, but by this time, and as a result of actions taken in Persian War battles, Athens had developed her own empire. Conflict mounted between the Athenians and the allies of Sparta. This conflict would lead to the Peloponnesian War during which the Persians opened their deep pockets to the Spartans. Medize Thucydides (3.61–67) says the Plataeans were the only Boeotians  who did not medize. To medize was to submit to the Persian king as overlord. The Greeks referred to the Persian forces collectively as Medes, not distinguishing Medes from Persians. Likewise, we today dont distinguish among the Greeks (Hellenes), but the Hellenes were not a united force before the Persian invasions. Individual poleis could make their own political decisions. Panhellenism (united Greeks) became important during the Persian Wars. Next, when the barbarian invaded Hellas, they say that they were the only Boeotians who did not Medize; and this is where they most glorify themselves and abuse us. We say that if they did not Medize, it was because the Athenians did not do so either; just as afterwards when the Athenians attacked the Hellenes they, the Plataeans, were again the only Boeotians who Atticized. ~Thucydides Individual Battles During the Persian Wars The Persian War was fought in a series of battles between the earliest at Naxos (502 BCE), when Naxos repelled the Persians to the final battle at Prosopitis, where Greek forces were besieged by the Persians, in 456 BCE. Arguably, the most significant battles of the War included Sardis, which was burned by the Greeks in 498 BCE; Marathon in 490 BCE, the first Persian invasion of Greece; Thermopylae (480), the second invasion after which the Persians took Athens; Salamis, when the combined Greek navy decisively beat the Persians in 480; and Plataea, where the Greeks effectively ended the second Persian invasion in 479. In 478, the Delian League was formed of several Greek city-states united to combine efforts under the leadership of Athens. Considered the start of the Athenian empire, the Delian League conducted several battles aimed at the expulsion of the Persians from Asian settlements, over a period of twenty years.   The main battles of the Persian Wars were: Conflict Origins: 1st Naxos, SardisIonian Revolt: Ephesus, LadeFirst Invasion: 2nd Naxos, Eretria, MarathonSecond Invasion: Thermopylae, Artemisium, Salamis, Plataea, MycaleGreek Counterattack: Mycale, Ionia, Sestos, Cyprus, ByzantiumDelian League: Eion, Doriskos, Eurymedon, Prosopitis End of the War The final battle of the war had led to the death of the Athenian leader Cimon and the defeat of the Persian forces in the area, but it didnt give decisive power in the Aegean to one side or the other. The Persians and Athenians were both tired and after Persian overtures, Pericles sent Callias to the Persian capital of Susa for negotiations. According to Diodorus, the terms gave the Greek poleis in Ionia their autonomy and the Athenians agreed not to campaign against the Persian king. The treaty is known as the Peace of Callias. Historical Sources Herodotus is the principal source on the Persian Wars, from Croesus of Lydias conquest of the Ionian poleis to the fall off Sestus (479 BCE).Thucydides provides some of the later material. There are also later historical writers, including Ephorus in the 4th century BCE, whose work is lost except for fragments, but was used byDiodorus Siculus, in the 1st century CE. Supplementing these are Justin (under Augustus) in his Epitome of Pompeius Trogus,Plutarch (2nd century CE) Biographies andPausanias (2nd century CE) Geography. In addition to historical sources, there is Aeschylus play The Persians. Key Figures Greek Miltiades (defeated the Persians at Marathon, 490)Themistocles (highly skilled Greek military leader during the Persian Wars)Eurybiades (Spartan leader in command of the Greek navy)Leonidas (king of Sparta, who died with his men at Thermopylae in 480)Pausanias (Spartan leader at Plataea)Cimon (Athenian leader after the wars supporting Sparta)Pericles (Athenian leader responsible for rebuilding Athens) Persian Darius I (fourth Persian king of the Achmaenids, ruled 522 to 486 BCE)Mardonius (military commander who died at the Battle of Plataea)Datis (Median admiral at Naxos and Eretria, and leader of the assault force at Marathon)Artaphernes (Persian satrap at Sardis, responsible for suppressing the Ionian revolt)Xerxes (ruler of the Persian empire, 486–465)Artabazus (Persian general in the second Persian invasion)Megabyzus (Persian general in the second Persian invasion) There were later battles between Romans and Persians, and even another war that might be thought of as Greco-Persian, the Byzantine-Sassanid War, in the 6th and early 7th century CE. Sources and Further Reading Aeschylus. The Persians: Seven against Thebes. Suppliants. Prometheus Bound. Ed. Sommerstein, Alan H. Cambridge: Harvard University Press, 2009.Green, Peter. The Greco-Persian Wars. Berkeley CA: University of California Press, 1996. Herodotus. The Landmark Herodotus: The Histories. Ed. Strassler, Robert B.; trans. Purvis, Andrea L. New York: Pantheon Books, 2007.Lenfant, Dominique. Greek Historians of Persia. A Companion to Greek and Roman Historiography. Ed. Marincola, John. Vol. 1. Malden MA: Blackwell Publishing, 2007. 200–09. Rung, Edward. Athens and the Achaemenid Persian Empire in 508/7 Bc: Prologue to the Conflict. Mediterranean Journal of Social Sciences 6 (2015): 257–62. Wardman, A. E. Herodotus on the Cause of the Greco-Persian Wars: (Herodotus, I, 5). The American Journal of Philology 82.2 (1961): 133–50.